Prof. Carole Ayoub Moubareck
Pharmacist (BSc) - Microbiologist (PhD)
PUBLICATIONS
“In the fields of observation chance favors only the prepared mind.”
- Louis Pasteur -
Journal Publications
Ayoub Moubareck C, Hammoudi Halat D. Bacterial pneumonia associated with multidrug-resistant Gram-negative pathogens:
Understanding epidemiology, resistance patterns, and implications with COVID-19. F1000 Research (Q1). 2024, 12:92.
Alatoom A, Alattas M, Alraddadi B, Ayoub Moubareck C, Hassanien A, Jamal W, Kurdi A, Mohamed N, Senok A, Somily AM,
Ziglam H. Antimicrobial resistance profiles of Pseudomonas aeruginosa in the Arabian Gulf region over a 12-year period (2010–
2021). Journal of Epidemiology and Global Health (Q1). 2024.
Thomsen J, Abdulrazzaq N, Nyasulu P, Al Hosani F, UAE AMR Surveillance Consortium, Menezes G, Senok A, Everett D, Ayoub Moubareck C. Epidemiology and Trends of Resistance of Mycobacterium spp. in the United Arab Emirates: A retrospective analysis of twelve years of National AMR Surveillance Data. Front. Public Health (Q1). 2024.
Thomsen J, Abdulrazzaq N, Oulhaj A, Nyasulu P, Alatoom A, Denning D, Dhaheri F, The UAE AMR Surveillance Consortium,
Menezes G, Senok A, Everett D, Ayoub Moubareck C. Emergence of highly resistant Candida auris in the United Arab Emirates:
A retrospective analysis of evolving trends. Front. Public Health (Q1). 2024, 11:1244358. doi: 10.3389/fpubh.2023.1244358
Thomsen J, Abdulrazzaq N, AlRand H, The UAE AMR Surveillance Consortium, Everett D, Senok A, Menezes G, Ayoub
Moubareck C. Epidemiology and antimicrobial resistance trends of Acinetobacter species in the United Arab Emirates: A
retrospective analysis of twelve years of National AMR Surveillance Data. Front. Public Health (Q1). 2024, 11:1245131. doi:
10.3389/fpubh.2023.1245131
Senok A, Thomsen J, Abdulrazzaq N, The UAE AMR Surveillance Consortium, Menezes G, Everett D, Ayoub Moubareck C.
Antimicrobial resistance in Streptococcus pneumoniae: A retrospective analysis of emerging trends in the United Arab Emirates from 2010-2021. Front. in Public Health (Q1). 2023, 11:1244357. doi: 10.3389/fpubh.2023.1244357
Thomsen J., Abdulrazzaq N, AlRand H, and The UAE AMR Surveillance Consortium (including Ayoub Moubareck C). Surveillance of Antimicrobial Resistance in the United Arab Emirates: The Early Implementation Phase. Front. Public Health (Q1). 2023, 11:1247627. doi: 10.3389/fpubh.2023.1247627
Thomsen J, Abdulrazzaq N, The UAE AMR Surveillance Consortium, Everett D, Menezes G, Senok A, Ayoub Moubareck C. Carbapenem Resistant Enterobacterales in the United Arab Emirates: A retrospective analysis from 2010-2021. Front. Public Health (Q1). 2023, 11:1244482. doi: 10.3389/fpubh.2023.1244482
Thomsen J, Abdulrazzaq N, The UAE AMR Surveillance Consortium, Menezes G, Everett D, Senok A, Ayoub Moubareck C.
Methicillin resistant Staphylococcus aureus in the United Arab Emirates: A twelve-year retrospective analysis of evolving trends.
Front. Public Health (Q1). 2023, 11:1244351. doi: 10.3389/fpubh.2023.1244351
Thomsen J, Menezes G, Abdulrazzaq N, The UAE AMR Surveillance Consortium, Senok A, Everett D, Ayoub Moubareck C.
Evolving Trends among Pseudomonas aeruginosa: A 12-Year Retrospective Study from the United Arab Emirates. Front. Public Health (Q1). 2023, 11:1243973. doi: 10.3389/fpubh.2023.1243973
Thomsen J, Abdulrazzaq N, AlRand H, The UAE AMR Surveillance Consortium, Menezes G, Ayoub Moubareck C. Everett D,
Senok A, Podbielski A. Epidemiology of Vancomycin-resistant Enterococci in the United Arab Emirates: A retrospective analysis
of twelve years of National AMR Surveillance Data. Front. Public Health (Q1). 2023, 11:1275778. doi: 10.3389/fpubh.2023.1275778
Ali Ahmad M, Karavetian M, Ayoub Moubareck C, Wazz G, Mahdi T, Venema K. Association of the gut microbiota with clinical variables in Obese and Lean Emirati subjects. Front. in microbiology (Q1). 2023, volume 14
Ayoub Moubareck C, Alawlaqi, B., Alhajeri, S. Characterization of physicochemical parameters and bacterial diversity of composted organic food wastes in Dubai. Heliyon (Q1). 2023, 9(6), e16426
Daoud L, Al Marzooq F, Ayoub Moubareck C, Ghazawi A, Collyns T. Elucidating the effect of iron acquisition systems in Klebsiella pneumoniae on susceptibility to the novel siderophore-cephalosporin Cefiderocol. PLoS ONE (Q1). 2022, Vol. 17, issue 12.
Hammoudi Halat D, Ayoub Moubareck C. The Intriguing Carbapenemases of Pseudomonas aeruginosa: Current Status, Genetic Profile, and Global Epidemiology. Yale Journal of Biology and Medicine (Q2). 2022, Vol. 95, issue 4, pp. 507-515.
Abou-Samra M, Venema K, Ayoub Moubareck C, Karavetian M. The association of Peptide Hormones with Glycemia, Dyslipidemia, and Obesity in Lebanese Individuals. Metabolites (Q2). 2022, 12, 1051. https://doi.org/10.3390/metabo12111051
Ayoub Moubareck C. The Effectiveness of Project-Based Learning on Emirati Undergraduate Students in a Microbiology Course. Learning and Teaching in Higher Education: Gulf Perspectives (Q4). 2022, Vol. 18 No. 2, pp. 95-106.
Ali Ahmad M., Karavetian M., Ayoub Moubareck C., Wazz G, Mahdi T, Venema K. The Association between Peptide Hormones
with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates. Nutrients (Q1). 2022, 14, 1271. https://doi.org/10.3390/nu14061271
Ayoub Moubareck C, Hammoudi Halat D. The collateral effects of COVID-19 pandemic on the status of carbapenemase producing pathogens. Frontiers in Cellular and Infection Microbiology (Q1). 2022, March; 12:1-11. doi: 10.3389/fcimb.2022.823626
Geitani R, Ayoub Moubareck C, Costes F, Marti L, Karam Sarkis D, Touqui L. Bactericidal effects and stability of LL-37 and CAMA in the presence of human lung epithelial cells. Microbes and Infection (Q2). 2022, 24, 104928:1-10.
Ayoub Moubareck C. Human Milk Microbiota and Oligosaccharides: A Glimpse into Benefits, Diversity, and Correlations. Nutrients (Q1). 2021, 13, 1123.
Ayoub Moubareck C, Halat DH, Nabi A, AlSharhan M, AlDeesi Z, Han A, Celiloglu H, Sarkis DK. Detection of OXA-23, GES-11 and NDM-1 among carbapenem-resistant Acinetobacter baumannii in Dubai: A preliminary study. Journal of Global Antimicrobial Resistance (Q2). 2021, Jan; 24: 27-28.
Ayoub Moubareck C. Polymyxins and bacterial membranes: A review of antibacterial activity and mechanisms of resistance. Membranes (Q2). 2020, Aug; 10, 181:1-30.
Polymyxins: Newly Revived Antibiotics
Graphical Abstract:
Ayoub Moubareck C. "Polymyxins and bacterial membranes: A review of antibacterial activity and mechanisms of resistance." Membranes (Q2). 2020, Aug; 10, 181:1-30.
Ayoub Moubareck C, Lootah M, Tahlak M, Venema K. Profiles of Human Milk Oligosaccharides and Their Relations to the Milk Microbiota of Breastfeeding Mothers in Dubai. Nutrients (Q1). 2020, Jun; 12 (6) 1727:1-15.
Ayoub Moubareck C, Geitani R, Zhengzhong Xu, Karam Sarkis D, Touqui L. Expression and roles of antimicrobial peptides in innate defense of airway mucosa: potential implication in cystic fibrosis. Frontiers in Immunology (Q1). 2020, Jun; 11:1198.
Ayoub Moubareck C, Halat DH. The current burden of carbapenemases: Review of significant properties and dissemination among gram-negative bacteria. Antibiotics (Q1). 2020, Apr; 9 (4) 186.
Ayoub Moubareck C, Halat DH, Sartawi M, Lawlor K, Sarkis DK, Alatoom A. Assessment of performance of CHROMagar KPC and Xpert Carba-R assay for the detection of carbapenem resistant bacteria in rectal swabs: First comparative study from Abu Dhabi, United Arab Emirates. Journal of Global Antimicrobial Resistance (Q2). 2020, Mar; 20:147-152.
Ayoub Moubareck C, Halat DH. Insights into Acinetobacter baumannii: A review of microbiological, virulence, and resistance traits in a threatening nosocomial pathogen. Antibiotics (Q1). 2020, Mar; 9 (3) 119.
Itani T, Ayoub Moubareck C, Mangin I, Butel MJ, Karam Sarkis D. Individual variations in intestinal microbiota were higher in preterm infants with necrotising enterocolitis than healthy controls. Acta Paediatrica (Brief report in Q1). 2019, Dec; 108 (12):2294-2295.
Ayoub Moubareck C, Halat D., Akkawi C., Nabi A., AlSharhan M., AlDeesi Z., Peters C., Celiloglu H., Sarkis D. Role of outer membrane permeability, efflux mechanism, and carbapenemases in carbapenem-nonsusceptible Pseudomonas aeruginosa from Dubai hospitals: Results of the first cross-sectional survey. International Journal of Infectious Diseases (Q1). 2019. Jul;84:143-150.
Geitani R, Ayoub Moubareck C, Touqui L, Karam Sarkis D. Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa. BMC Microbiol (Q2). 2019 Mar 8;19(1):54.
Ayoub Moubareck C, Mouftah S., Pál T., Ghazawi A., Halat D., Nabi A., AlSharhan M., AlDeesi Z., Peters C., Celiloglu H., Sannegowda M., Sarkis D., Sonnevend A. Clonal emergence of Klebsiella pneumoniae ST14 co-producing OXA-48-type and NDM carbapenemases with high rate of colistin resistance in Dubai, United Arab Emirates. International Journal of Antimicrobial Agents (Q1). 2018, Jul; 52(1):90-95.
Itani T, Ayoub Moubareck C, Melki I, Rousseau C, Mangin I, Butel MJ, Karam Sarkis D. Preterm infants with necrotising enterocolitis demonstrate an unbalanced gut microbiota. Acta Paediatrica (Q2). 2018, Jan 107 (1) :40-47.
Hammoudi Halat, D., Ayoub Moubareck, C., Karam Sarkis, D. Heterogeneity of carbapenem resistance mechanisms among Gram-negative pathogens in Lebanon: results of the first cross-sectional countrywide study. Microbial Drug Resistance. 2017, Sep; 23(6):733-743.
Itani T, Ayoub Moubareck C, Melki I, Rousseau C, Mangin I, Butel MJ, Karam Sarkis D. Establishment and development of the intestinal microbiota of preterm infants in a Lebanese tertiary hospital. Anaerobe. 2017 Feb: 43:4-14.
D. Hammoudi, C. Ayoub Moubareck, N. Hakime, M. Houmani, A. Barakat, Z. Najjar, M. Suleiman, N. Fayad, R. Sarraf, D. Karam Sarkis. Spread of imipenem-resistant Acinetobacter baumannii co-expressing OXA-23 and GES-11 carbapenemases in Lebanon. International Journal of Infectious Diseases 36 (2015), 56–61
D. Hammoudi, C. Ayoub Moubareck, D. Karam Sarkis. How to detect carbapenemase producers? A literature review of phenotypic and molecular methods. Journal of Microbiological Methods 107 (2014), 106–118
D. Hammoudi, C. Ayoub Moubareck, J. Aires, A. Adaime, A. Barakat, N. Fayad, N. Hakime, M. Houmani, T. Itani, Z. Najjar, M. Suleiman, R. Sarraf, D. Karam Sarkis. Countrywide spread of OXA-48 carbapenemase in Lebanon:surveillance and genetic characterization of carbapenem-non-susceptible Enterobacteriaceae in 10 hospitals over a one-year period. International Journal of Infectious Diseases 29 (2014) 139–144
A. Morvan, C. Moubareck, A. Leclercq, M. Herve´-Bazin, S. Bremont, M. Lecuit, P. Courvalin, A. Le Monnier. Antimicrobial Resistance of Listeria monocytogenes Strains Isolated from Humans in France. Antimicrobial Agents And Chemotherapy 54 (2010), 2728–2731
Moubareck C., Meziane-Cherif D., Courvalin P., Périchon B. 2009. VanA type Staphylococcus aureus VRSA-7 is dependent on vancomycin for growth. Antimicrobial Agents and Chemotherapy (Q1). 53(9):3657-63.
Staphylococcus aureus Partially Dependent on Vancomycin for Growth
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Publication:
Moubareck C., Meziane-Cherif D., Courvalin P., Périchon B. 2009. VanA type Staphylococcus aureus VRSA-7 is dependent on vancomycin for growth. Antimicrobial Agents and Chemotherapy (Q1). 53(9):3657-63. [PDF available above]
C. Moubareck, S. Bremont, Marie-Christine Conroy, P. Courvalin, T. Lambert. GES-11, a Novel Integron-Associated GES Variant in Acinetobacter baumannii. Antimicrobial Agents And Chemotherapy 53 (2009), 3579–3581
Ziad Daoud, Carole Moubareck, Noha Hakime, Florence Doucet-Populaire. Extended spectrum beta-lactamase producing Enterobacteriaceae in Lebanese ICU patients: Epidemiology and patterns of resistance. J. Gen. Appl. Microbiol. 52 (2006), p. 169–178
Nadege Bourgeois-Nicolaos, Carole Moubareck, Nicole Mangeney, Marie-Jose Butel, Florence Doucet-Populaire. Comparative study of vanA gene transfer from Enterococcus faecium to Enterococcus faecalis and to Enterococcus faecium in the intestine of mice. FEMS Microbiol. Lett. 254 (2006), p. 27–33
C. Moubareck, F. Doucet-Populaire, M. Hamze, Z. Daoud, F.-X. Weill. First Extended-Spectrum--Lactamase (CTX-M-15)-ProducingSalmonella enterica Serotype TyphimuriumIsolate Identified in Lebanon. Antimicrobial Agents And Chemotherapy 49 (2005), p. 864–865
C. Moubareck, N. Bourgeois, P. Courvalin, F. Doucet-Populaire. Multiple Antibiotic Resistance Gene Transfer from Animal to HumanEnterococci in the Digestive Tract of Gnotobiotic Mice. Antimicrobial Agents And Chemotherapy 47 (2003), p. 2993–2996
Book Chapters
Ayoub Moubareck C, Geitani R, Zhengzhong Xu, Karam Sarkis D, Touqui L. Expression and roles of antimicrobial peptides in innate defense of airway mucosa: potential implication in cystic fibrosis. Chapter in the book “Immune Responses of the Mucosal Epithelium in Chronic Lung Diseases”; published by Frontiers in Immunology in June 2020, pp 325-361.
Hammoudi D, Karam Sarkis D, Ayoub Moubareck C. Carbapenem Resistant Gram-negative Bacilli: The state of the Art. Chapter in the book “Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches”; published by Elsevier in June 2016, pp 93-119.
Theses of PhD Graduates under My Supervision
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Saint Joseph University - Lebanon in collaboration with the Institut Pasteur - France,
Regina Geitani (graduated July 2020)
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Saint Joseph University - Lebanon in collaboration with Paris Descartes University - France, Tarek Itani (graduated July 2017)
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Saint Joseph University - Lebanon in collaboration with the Institut Pasteur - France,
Dalal Hammoudi (graduated January 2015)
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